Medicinal Ingredients and Clinical Trials
Yurika! - the certified botanical solution for menstrual cramps.
Note - menstrual cramps, period pain and primary dysmenorrhea are used interchangeably.
Yurika! Medicinal Ingredients
Yurika! is a unique compound of two therapeutic botanicals:
Bitter Fennel Mill (Seed)
- anti-spasmodic, analgesic, anti-inflammatory
- analgesic, anti-inflammatory, antiemetic, bio-enhancer
This post presents evidence that both bitter fennel seed and ginger rhizome have proven to relieve menstrual cramps.
In combination however, their synergism has greatly amplified the medicinal value.
This is why women taking Yurika! regularly experience the complete prevention or elimination of period pain.
Monographs & Clinical Trials
Bitter Fennel Seed (Mill)
- Latin - foeniculum vulgare
Health Canada Monograph
Use(s) / Seed
Traditionally used in Herbal Medicine to help relieve the pain associated with menstruation.
No statement is required
Note - Bitter fennel seed first appeared in the European Medicines Agency monograph (2007) as “an effective treatment for menstrual cramps.”
Case #1 Effect of fennel on pain intensity in dysmenorrhoea: A placebo-controlled trial.
AYU Journal 2012 // S. Omidvar // Cited by 29 related articles
Objective: The aim of this study was to determine the clinical effect of Foeniculum vulgare on primary dysmenorrhoea.
Method: A placebo controlled double blind clinical study, involving 60 young women aged 15 to 24 years.
Conclusion: Available evidence suggests that... fennel can be used to significantly relieve the signs and symptoms of primary dysmenorrhoea.
Case #2 Fennel For Dysmenorrhea
Integrative Medicine (Fourth Edition) 2018 // Greta J. Kuphal MD, re-published in Science Direct
Conclusion: In a study of different doses, Fennel reduced the intensity of oxytocin and PGE2 induced contractions significantly. Fennel also reduced the frequency of contractions induced by PGE2...”
- Latin - zingiber officinale
Case #1 Comparison of Ginger Rhizome, Mefenamic Acid and Ibuprofen on Pain in Women With Primary Dysmenorrhea: Double-Blind Comparative Clinical Trial
Published in The Journal of Alternative and Complementary Medicine - Volume 15, Number 2, 2009, pp. 129–132
© Mary Ann Liebert, Inc. DOI: 10.1089/acm.2008.0311
Objectives: To compare the effects of ginger, mefenamic acid, and ibuprofen on pain in women with primary dysmenorrhea.
Methods: This was a double-blind comparative clinical trial conducted from September 2006 to February 2007. Participants were 150 students (18 years old and over) with primary dysmenorrhea...
Conclusion: Ginger was as effective as mefenamic acid and ibuprofen in relieving pain in women with primary dysmenorrhea
Case #2 Efficacy of Ginger for Alleviating the Symptoms of Primary Dysmenorrhea: A Systematic Review and Meta-analysis of Randomized Clinical Trials
Wiley Online Library
First published: 14 July 2015
Objective: There has been no attempt to date to synthesize the available evidence for the efficacy of ginger for treating primary dysmenorrhea. This systematic review evaluates the current evidence for the effectiveness of ginger for treating primary dysmenorrhea.
Method: Literature searches were conducted using 12 electronic databases including: PubMed, EMBASE, Cochrane Library, Korean databases, Chinese medical databases, and Indian scientific database
Results: Initial searches yielded 29 articles. Of these original results, seven met specific selection criteria
Conclusion: Collectively these RCTs [Registered Clinical Trials] provide suggestive evidence for the effectiveness of ginger powder during the first 3–4 days of menstrual cycle for primary dysmenorrhea.
Case #3 The effect of mefenamic acid and ginger on pain relief in primary dysmenorrhea: A randomized clinical trial
Archives of Gynecology and Obstetrics 16(6) · November 2014 with 1,429 Reads
Purpose: The aim of the study was to compare the effect of mefenamic acid and ginger on pain management in primary dysmenorrhea.
Methods: One hundred and twenty-two female students with moderate to severe primary dysmenorrhea were randomly allocated to the ginger and mefenamic groups in a randomized clinical trial.
Conclusion: Ginger is as effective as mefenamic acid on pain relief in primary dysmenorrhea. Ginger does not have adverse effects and is an alternative treatment for primary dysmenorrhea.
Citations 23 // References 50
Case #4 Ginger For the Treatment of Painful Menses: Cochrane Meta-Analysis
Indiana University School of Nursing and the University of Wisconsin-Madison’s School of Nursing
Conclusion: The researchers found six studies that met the criteria for a Cochrane meta-analysis and concluded that ginger effectively reduces menses pain.
1. Ginger is a well known antiemetic, effective against nausea and vomiting.
- Ginger / Zingiber Officinale
Use(s) or Purpose(s)
Help(s) prevent nausea and vomiting
No statement is required
2. Ginger Demonstrates a Significant Compounding Effect
Another randomized controlled trial with 150 participants demonstrated that ginger reduced the pain of primary dysmenorrhea even more during the second month of treatment. There was a significant compounding effect.
Copyright © 2014 American Society for Pain Management Nursing. All rights reserved.
3. Ginger Reduces Menstrual Blood Loss Related to Iron Deficiency Anemia
Ginger appears to be a highly effective treatment for the reduction of menstrual blood loss. This is important since up to 18 million young women in the United States experience iron deficiency anemia due to heavy menstrual bleeding.
4. Ginger is a Bio-enhancer
Bio-enhancers are chemical entities which promote and augment the bioavailability of the drugs which are mixed with them. In this case, ginger enhances the therapeutic value of bitter fennel.
Glossary of Medical Terms:
analgesic - a substance that reduces or eliminates pain
antiemetic - preventing nausea and vomiting
anti-inflammatory - reducing or counteracting inflammation
antispasmodic - relieving spasms and preventing cramps
bio-enhancer - a substance that increases the bioavailability and effectiveness of active substances with which they are combined
botanical - a plant used as medicine (medical botany)
monograph - a detailed written study of a single specialized subject
synergism - an interaction of individual agents such that the total effect is greater than the sum of the individual effects